Ontology highlight
ABSTRACT:
SUBMITTER: Moskowitz M
PROVIDER: S-EPMC6444906 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Moskowitz Max M Wolf Christian C
Angewandte Chemie (International ed. in English) 20190214 11
The highly enantioselective addition of terminal ynamides to a variety of isatins, catalyzed by a bisoxazolidine copper complex under mild, base-free reaction conditions, is described. The reaction is broad in scope, scalable, applicable to unprotected isatins, and provides efficient access to 3-hydroxyoxindoles carrying a tetrasubstituted chiral center with excellent yields and enantioselectivities. Synthetically versatile, multifunctional 3-hydroxyindolinones are obtained by hydration, partial ...[more]