Ontology highlight
ABSTRACT:
SUBMITTER: Renault P
PROVIDER: S-EPMC6445292 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Renault Pedro P Louet Maxime M Marie Jacky J Labesse Gilles G Floquet Nicolas N
Scientific reports 20190402 1
Through their coupling to G proteins, G Protein-Coupled Receptors (GPCRs) trigger cellular responses to various signals. Some recent experiments have interestingly demonstrated that the G protein can also act on the receptor by favoring a closed conformation of its orthosteric site, even in the absence of a bound agonist. In this work, we explored such an allosteric modulation by performing extensive molecular dynamics simulations on the adenosine A2 receptor (A2AR) coupled to the Mini-Gs protei ...[more]