Ontology highlight
ABSTRACT:
SUBMITTER: Bissaro M
PROVIDER: S-EPMC6695830 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Bissaro Maicol M Bolcato Giovanni G Deganutti Giuseppe G Sturlese Mattia M Moro Stefano S
Molecules (Basel, Switzerland) 20190729 15
One of the most intriguing findings highlighted from G protein-coupled receptor (GPCR) crystallography is the presence, in many members of class A, of a partially hydrated sodium ion in the middle of the seven transmembrane helices (7TM) bundle. In particular, the human adenosine A<sub>2A</sub> receptor (A<sub>2A</sub> AR) is the first GPCR in which a monovalent sodium ion was crystallized in a distal site from the canonical orthosteric one, corroborating, from a structural point of view, its ro ...[more]