In silico Characterization of Human Prion-Like Proteins: Beyond Neurological Diseases.

ABSTRACT: Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the regulation of processes such as transcription and translation in multiple species. Here, we perform a stringent computational survey to identify prion-like proteins in the human proteome. We detected 242 candidate polypeptides and computationally assessed their function, protein-protein interaction networks, tissular expression, and their link to disease. Human prion-like proteins constitute a subset of modular polypeptides broadly expressed across different cell types and tissues, significantly associated with disease, embedded in highly connected interaction networks, and in

SUBMITTER: Iglesias V 

PROVIDER: S-EPMC6445884 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature