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Human Endogenous Retroviruses in Neurological Diseases.

ABSTRACT: The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components, normally dormant within human genomes, has been identified: human endogenous retroviruses (HERVs). These represent ?8% of the human genome, and environmental factors have reproducibly been shown to trigger their expression. The resulting production of envelope (Env) proteins from HERV-W and HERV-K appears to engage pathophysiological pathways leading to the pathognomonic features of MS and ALS, respectively. Pathogenic HERV elements may thus provide a missing link in understanding these complex diseases. Moreover, their neutralization may represent a promising strategy to establish novel and more powerful therapeutic approaches.

SUBMITTER: Kury P

PROVIDER: S-EPMC7185488 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Human Endogenous Retroviruses in Neurological Diseases.

Küry Patrick P Nath Avindra A Créange Alain A Dolei Antonina A Marche Patrice P Gold Julian J Giovannoni Gavin G Hartung Hans-Peter HP Perron Hervé H

Trends in molecular medicine 20180315 4

The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components, normally dormant within human genomes, has been identified: human endogenous retroviruses (HERVs). These represent ∼8% of the human genome, and environmental factors have reproducibly been shown to trigger their expression. The resulting production of envelope (Env) proteins from HERV-W and HERV-K appears to engage pathophysiological pathways leading to the path ...[more]

PMID: 29551251

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Project description: Not available

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An immune-suppressing protein in human endogenous retroviruses.

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