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The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome.

ABSTRACT: Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.

SUBMITTER: McBride A

PROVIDER: S-EPMC6445951 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome.

McBride Amanda A Houtmann Sarah S Wilde Lindsay L Vigil Carlos C Eischen Christine M CM Kasner Margaret M Palmisiano Neil N

Frontiers in oncology 20190327

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS. ...[more]

PMID: 30972300

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