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Clinical correlates of lung ventilation defects in asthmatic children.


ABSTRACT:

Background

Lung ventilation defects identified by using hyperpolarized 3-helium gas ((3)He) lung magnetic resonance imaging (MRI) are prevalent in asthmatic patients, but the clinical importance of ventilation defects is poorly understood.

Objectives

We sought to correlate the lung defect volume quantified by using (3)He MRI with clinical features in children with mild and severe asthma.

Methods

Thirty-one children with asthma (median age, 10 years; age range, 3-17 years) underwent detailed characterization and (3)He lung MRI. Quantification of the (3)He signal defined ventilation defect and hypoventilated, ventilated, and well-ventilated volumes.

Results

The ventilation defect to total lung volume fraction ranged from 0.1% to 11.6%. Children with ventilation defect percentages in the upper tercile were more likely to have severe asthma than children in the lower terciles (P = .005). The ventilation defect percentage correlated (P < .05 for all) positively with the inhaled corticosteroid dose, total number of controller medications, and total blood eosinophil counts and negatively with the Asthma Control Test score, FEV1 (percent predicted), FEV1/forced vital capacity ratio (percent predicted), and forced expiratory flow rate from 25% to 75% of expired volume (percent predicted).

Conclusion

The lung defect volume percentage measured by using (3)He MRI correlates with several clinical features of asthma, including severity, symptom score, medication requirement, airway physiology, and atopic markers.

SUBMITTER: Altes TA 

PROVIDER: S-EPMC6447058 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Publications

Clinical correlates of lung ventilation defects in asthmatic children.

Altes Talissa A TA   Mugler John P JP   Ruppert Kai K   Tustison Nicholas J NJ   Gersbach Joanne J   Szentpetery Sylvia S   Meyer Craig H CH   de Lange Eduard E EE   Teague W Gerald WG  

The Journal of allergy and clinical immunology 20151029 3


<h4>Background</h4>Lung ventilation defects identified by using hyperpolarized 3-helium gas ((3)He) lung magnetic resonance imaging (MRI) are prevalent in asthmatic patients, but the clinical importance of ventilation defects is poorly understood.<h4>Objectives</h4>We sought to correlate the lung defect volume quantified by using (3)He MRI with clinical features in children with mild and severe asthma.<h4>Methods</h4>Thirty-one children with asthma (median age, 10 years; age range, 3-17 years) u  ...[more]

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