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Clinical correlates of lung ventilation defects in asthmatic children.


ABSTRACT: BACKGROUND:Lung ventilation defects identified by using hyperpolarized 3-helium gas ((3)He) lung magnetic resonance imaging (MRI) are prevalent in asthmatic patients, but the clinical importance of ventilation defects is poorly understood. OBJECTIVES:We sought to correlate the lung defect volume quantified by using (3)He MRI with clinical features in children with mild and severe asthma. METHODS:Thirty-one children with asthma (median age, 10 years; age range, 3-17 years) underwent detailed characterization and (3)He lung MRI. Quantification of the (3)He signal defined ventilation defect and hypoventilated, ventilated, and well-ventilated volumes. RESULTS:The ventilation defect to total lung volume fraction ranged from 0.1% to 11.6%. Children with ventilation defect percentages in the upper tercile were more likely to have severe asthma than children in the lower terciles (P = .005). The ventilation defect percentage correlated (P < .05 for all) positively with the inhaled corticosteroid dose, total number of controller medications, and total blood eosinophil counts and negatively with the Asthma Control Test score, FEV1 (percent predicted), FEV1/forced vital capacity ratio (percent predicted), and forced expiratory flow rate from 25% to 75% of expired volume (percent predicted). CONCLUSION:The lung defect volume percentage measured by using (3)He MRI correlates with several clinical features of asthma, including severity, symptom score, medication requirement, airway physiology, and atopic markers.

SUBMITTER: Altes TA 

PROVIDER: S-EPMC6447058 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Clinical correlates of lung ventilation defects in asthmatic children.

Altes Talissa A TA   Mugler John P JP   Ruppert Kai K   Tustison Nicholas J NJ   Gersbach Joanne J   Szentpetery Sylvia S   Meyer Craig H CH   de Lange Eduard E EE   Teague W Gerald WG  

The Journal of allergy and clinical immunology 20151029 3


<h4>Background</h4>Lung ventilation defects identified by using hyperpolarized 3-helium gas ((3)He) lung magnetic resonance imaging (MRI) are prevalent in asthmatic patients, but the clinical importance of ventilation defects is poorly understood.<h4>Objectives</h4>We sought to correlate the lung defect volume quantified by using (3)He MRI with clinical features in children with mild and severe asthma.<h4>Methods</h4>Thirty-one children with asthma (median age, 10 years; age range, 3-17 years) u  ...[more]

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