Ontology highlight
ABSTRACT:
SUBMITTER: Pfitzer L
PROVIDER: S-EPMC6447524 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Pfitzer Lisa L Moser Christina C Gegenfurtner Florian F Arner Anja A Foerster Florian F Atzberger Carina C Zisis Themistoklis T Kubisch-Dohmen Rebekka R Busse Johanna J Smith Rebecca R Timinszky Gyula G Kalinina Olga V OV Müller Rolf R Wagner Ernst E Vollmar Angelika M AM Zahler Stefan S
Cell death & disease 20190403 4
Severe side effects often restrict clinical application of the widely used chemotherapeutic drug doxorubicin. In order to decrease required substance concentrations, new concepts for successful combination therapy are needed. Since doxorubicin causes DNA damage, combination with compounds that modulate DNA repair could be a promising strategy. Very recently, a role of nuclear actin for DNA damage repair has been proposed, making actin a potential target for cancer therapy in combination with DNA ...[more]