Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC7232544 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in pharmacology 20200507
Defects in DNA damage repair may cause genome instability and cancer development. The tumor suppressor gene p53 regulates cell cycle arrest to allow time for DNA repair. The oncoprotein mouse double minute 2 (MDM2) promotes cell survival, proliferation, invasion, and therapeutic resistance in many types of cancer. The major role of MDM2 is to inhibit p53 activity and promote its degradation. In this review, we describe the influence of MDM2 on genomic instability, the role of MDM2 on releasing p ...[more]