Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC6448791 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Chen Zhong Z Duan Huaqing H Tong Xiaohang X Hsu Peiling P Han Li L Morris-Natschke Susan L SL Yang Shilin S Liu Wei W Lee Kuo-Hsiung KH
Journal of natural products 20171113 3
The strong hemolytic toxicity of pulsatilla saponin D (1, HD<sub>50</sub> 6.3 μM) has hampered its clinical development as an injectable anticancer agent. To combat this challenge, 17 new derivatives of 1 with ring C, C-28, or C-3 modifications were synthesized and evaluated for cytotoxicity against several selected human tumor lines, as well as for hemolytic toxicity against rabbit erythrocytes. Structure-activity relationship (SAR) and structure-toxicity relationship (STR) correlations were al ...[more]