Ontology highlight
ABSTRACT:
SUBMITTER: Newcomer RL
PROVIDER: S-EPMC6449081 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Newcomer Rebecca L RL Schrad Jason R JR Gilcrease Eddie B EB Casjens Sherwood R SR Feig Michael M Teschke Carolyn M CM Alexandrescu Andrei T AT Parent Kristin N KN
eLife 20190404
The major coat proteins of dsDNA tailed phages (order <i>Caudovirales</i>) and herpesviruses form capsids by a mechanism that includes active packaging of the dsDNA genome into a precursor procapsid, followed by expansion and stabilization of the capsid. These viruses have evolved diverse strategies to fortify their capsids, such as non-covalent binding of auxiliary 'decoration' (Dec) proteins. The Dec protein from the P22-like phage L has a highly unusual binding strategy that distinguishes bet ...[more]