Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.

ABSTRACT: BACKGROUND:The liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates. PURPOSE:To identify the most influential covariates for liver R2* values in patients with nonalcoholic fatty liver disease (NAFLD). STUDY TYPE:Retrospective analysis of prospectively acquired data. POPULATION:Baseline data from 204 subjects enrolled in NAFLD/NASH (nonalcoholic steatohepatitis) treatment trials. FIELD STRENGTH:1.5T and 3T; chemical-shift encoded multiecho gradient echo. ASSESSMENT:Correlation between liver proton density fat fraction and R2*; assessment for demographic, metabolic, laboratory, MRI-derived, and histological covariates of liver R2*. STATISTICAL TESTS:Pearson's and Spearman's correlations; univariate analysis; gradient boosting machines (GBM) multivariable machine-learning method. RESULTS:Hepatic proton density fat fraction (PDFF) was the most strongly correlated covariate for R2* at both 1.5T (r?=?0.652, P?

SUBMITTER: Bashir MR 

PROVIDER: S-EPMC6449180 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature