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Annexin 1-nuclear factor-?B-microRNA-26a regulatory pathway in the metastasis of non-small cell lung cancer.

ABSTRACT:

Background

Annexin 1 (ANXA1) expression is associated with the malignant tumor phenotype, making it an attractive therapeutic target. However, little is known about the regulation of ANXA1 in non-small cell lung cancer (NSCLC).

Methods

We investigated the biological roles of ANXA1 in tumor growth, migration, and invasion, and explored the possibility of ANXA1 as a potential therapeutic target for the treatment of NSCLC.

Results

Our findings revealed that ANXA1 enhanced nuclear factor (NF)-?B activation in NSCLC cells by interaction with inhibitor of NF-?B kinase complex subunit, IKK?. We also found that NF-?B could negatively regulate microRNA (miR)-26a, and miR-26a was regulated through the ANXA1-NF-?B regulatory pathway. NF-?B activation negatively regulated by miR-26a was confirmed in NSCLC.

Conclusion

Together, these results provide evidence of the mechanisms of the ANXA1-NF-?B-miR-26a regulatory pathway in the invasion and migration in NSCLC.

SUBMITTER: Guan X

PROVIDER: S-EPMC6449244 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Annexin 1-nuclear factor-κB-microRNA-26a regulatory pathway in the metastasis of non-small cell lung cancer.

Guan Xiaoying X Fang Ying Y Long Jie J Zhang Yajie Y

Thoracic cancer 20190212 4

<h4>Background</h4>Annexin 1 (ANXA1) expression is associated with the malignant tumor phenotype, making it an attractive therapeutic target. However, little is known about the regulation of ANXA1 in non-small cell lung cancer (NSCLC).<h4>Methods</h4>We investigated the biological roles of ANXA1 in tumor growth, migration, and invasion, and explored the possibility of ANXA1 as a potential therapeutic target for the treatment of NSCLC.<h4>Results</h4>Our findings revealed that ANXA1 enhanced nucl ...[more]

PMID: 30756482

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