Increases of desmin and ?-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction.
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ABSTRACT:
SUBMITTER: Sheng JJ
PROVIDER: S-EPMC6449858 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
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Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction.
Sheng Juan-Juan JJ Feng Han-Zhong HZ Pinto Jose R JR Wei Hongguang H Jin J-P JP
Journal of molecular and cellular cardiology 20151102
Up-regulation of desmin has been reported in cardiac hypertrophy and failure but the pathophysiological cause and significance remain to be investigated. By examining genetically modified mouse models representative for diastolic or systolic heart failure, we found significantly increased levels of desmin and α-actinin in the myofibrils of hearts with impaired diastolic function but not hearts with weakened systolic function. The increased desmin and α-actinin are mainly found in myofibrils at t ...[more]
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