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Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility.

ABSTRACT: BACKGROUND:The aim of this study was to screen for noise-induced hearing loss (NIHL)-associated single nucleotide polymorphisms (SNPs) and to construct genetic risk prediction models for NIHL in a Chinese population. METHODS:Four hundred seventy-six subjects with NIHL and 476 matched controls were recruited from a cross-sectional survey on NIHL in China. A total of 83 candidate SNPs were genotyped using nanofluidic dynamic arrays on a Fluidigm platform. NIHL-associated SNPs were screened with a multiple logistic model, and a genetic risk model was constructed based on the genetic risk score (GRS). The results were validated using a prospective cohort population. RESULTS:Seven SNPs in the CDH23, PCDH15, EYA4, MYO1A, KCNMA1, and OTOG genes were significantly (P??0.05 and P?

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6449917 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility.

Zhang Xuhui X   Ni Yaqin Y   Liu Yi Y   Zhang Lei L   Zhang Meibian M   Fang Xinyan X   Yang Zhangping Z   Wang Qiang Q   Li Hao H   Xia Yuyong Y   Zhu Yimin Y  

Environmental health : a global access science source 20190404 1

<h4>Background</h4>The aim of this study was to screen for noise-induced hearing loss (NIHL)-associated single nucleotide polymorphisms (SNPs) and to construct genetic risk prediction models for NIHL in a Chinese population.<h4>Methods</h4>Four hundred seventy-six subjects with NIHL and 476 matched controls were recruited from a cross-sectional survey on NIHL in China. A total of 83 candidate SNPs were genotyped using nanofluidic dynamic arrays on a Fluidigm platform. NIHL-associated SNPs were s  ...[more]

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