Ontology highlight
ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC6450672 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lin Yanxian Y McCarty James J Rauch Jennifer N JN Delaney Kris T KT Kosik Kenneth S KS Fredrickson Glenn H GH Shea Joan-Emma JE Han Songi S
eLife 20190405
The mechanism that leads to liquid-liquid phase separation (LLPS) of the tau protein, whose pathological aggregation is implicated in neurodegenerative disorders, is not well understood. Establishing a phase diagram that delineates the boundaries of phase co-existence is key to understanding whether LLPS is an equilibrium or intermediate state. We demonstrate that tau and RNA reversibly form complex coacervates. While the equilibrium phase diagram can be fit to an analytical theory, a more advan ...[more]