Ontology highlight
ABSTRACT:
SUBMITTER: Dudbridge F
PROVIDER: S-EPMC6450903 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Dudbridge Frank F Allen Richard J RJ Sheehan Nuala A NA Schmidt A Floriaan AF Lee James C JC Jenkins R Gisli RG Wain Louise V LV Hingorani Aroon D AD Patel Riyaz S RS
Nature communications 20190405 1
Following numerous genome-wide association studies of disease susceptibility, there is increasing interest in genetic associations with prognosis, survival or other subsequent events. Such associations are vulnerable to index event bias, by which selection of subjects according to disease status creates biased associations if common causes of incidence and prognosis are not accounted for. We propose an adjustment for index event bias using the residuals from the regression of genetic effects on ...[more]