Ontology highlight
ABSTRACT:
SUBMITTER: Chan-Yao-Chong M
PROVIDER: S-EPMC6451034 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Chan-Yao-Chong Maud M Deville Célia C Pinet Louise L van Heijenoort Carine C Durand Dominique D Ha-Duong Tâp T
Biophysical journal 20190226 7
Because of their large conformational heterogeneity, structural characterization of intrinsically disordered proteins (IDPs) is very challenging using classical experimental methods alone. In this study, we use NMR and small-angle x-ray scattering (SAXS) data with multiple molecular dynamics (MD) simulations to describe the conformational ensemble of the fully disordered verprolin homology domain of the neural Aldrich syndrome protein involved in the regulation of actin polymerization. First, we ...[more]