Ontology highlight
ABSTRACT:
SUBMITTER: Hiraiwa T
PROVIDER: S-EPMC6451396 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Hiraiwa Takumi T Yamada Takahiro G TG Miki Norihisa N Funahashi Akira A Hiroi Noriko N
Journal of the Royal Society, Interface 20190301 152
Neuroblastoma is the most common solid tumour of childhood, and it metastasizes to distant organs. However, the mechanism of metastasis, which generally depends on the cell motility of the neuroblastoma, remains unclear. In many solid tumours, it has been reported that shear stress promotes metastasis. Here, we investigated the relationship between shear stress and cell motility in the MYCN-amplified human neuroblastoma cell line IMR32, using a microfluidic device. We confirmed that most of the ...[more]