Ontology highlight
ABSTRACT:
SUBMITTER: Olenick MA
PROVIDER: S-EPMC6451413 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Olenick Mara A MA Holzbaur Erika L F ELF
Journal of cell science 20190315 6
Cytoplasmic dynein-1 (hereafter dynein) is an essential cellular motor that drives the movement of diverse cargos along the microtubule cytoskeleton, including organelles, vesicles and RNAs. A long-standing question is how a single form of dynein can be adapted to a wide range of cellular functions in both interphase and mitosis. Recent progress has provided new insights - dynein interacts with a group of activating adaptors that provide cargo-specific and/or function-specific regulation of the ...[more]