Ontology highlight
ABSTRACT:
SUBMITTER: Hwang MS
PROVIDER: S-EPMC6451419 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Hwang Ming-Shih MS Strainic Michael G MG Pohlmann Elliot E Kim Haesuk H Pluskota Elzbieta E Ramirez-Bergeron Diana L DL Plow Edward F EF Medof M Edward ME
Journal of cell science 20190328 6
Purified vascular endothelial cell (EC) growth factor receptor-2 (VEGFR2) auto-phosphorylates upon VEGF-A occupation <i>in vitro</i>, arguing that VEGR2 confers its mitotic and viability signaling in and of itself. Herein, we show that, in ECs, VEGFR2 function requires concurrent C3a/C5a receptor (C3ar1/C5ar1) and IL-6 receptor (IL-6R)-gp130 co-signaling. C3ar1/C5ar1 or IL-6R blockade totally abolished VEGFR2 auto-phosphorylation, downstream Src, ERK, AKT, mTOR and STAT3 activation, and EC cell ...[more]