Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity.
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ABSTRACT:
SUBMITTER: Pan HX
PROVIDER: S-EPMC6451440 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity.
Pan Hai-Xue HX Chen Zhang Z Zeng Tianfang T Jin Wen-Bing WB Geng Yujie Y Lin Geng-Min GM Zhao Juan J Li Wei-Tao WT Xiong Zijun Z Huang Sheng-Xiong SX Zhai Xin X Liu Hung-Wen HW Tang Gong-Li GL
Organic letters 20190214 5
The biosynthetic gene clusters for herbicidins ( hbc) and aureonuclemycin ( anm) were identified in Streptomyces sp. KIB-027 and Streptomyces aureus, respectively. The roles of genes possibly involved in post-core-assembly steps in herbicidin biosynthesis in these clusters and a related her cluster were studied. Through systematic gene deletions, structural elucidation of the accumulated intermediates in the mutants, and in vitro verification of the encoded enzymes, the peripheral modification p ...[more]
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