Ontology highlight
ABSTRACT:
SUBMITTER: Tran TAT
PROVIDER: S-EPMC6453527 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tran Thi Anh Thu TAT Grievink Hendrika W HW Lipinska Katarzyna K Kluft Cornelis C Burggraaf Jacobus J Moerland Matthijs M Tasev Dimitar D Malone Karen E KE
PloS one 20190408 4
Processing of pro-interleukin (IL)-1β and IL-18 is regulated by multiprotein complexes, known as inflammasomes. Inflammasome activation results in generation of bioactive IL-1β and IL-18, which can exert potent pro-inflammatory effects. Our aim was to develop a whole blood-based assay to study the inflammasome in vitro and that also can be used as an assay in clinical studies. We show whole blood is a suitable milieu to study inflammasome activation in primary human monocytes. We demonstrated th ...[more]