Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC6453541 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wang Congzhou C Sudlow Gail G Wang Zheyu Z Cao Sisi S Jiang Qisheng Q Neiner Alicia A Morrissey Jeremiah J JJ Kharasch Evan D ED Achilefu Samuel S Singamaneni Srikanth S
Advanced healthcare materials 20181019 22
Protein therapeutics are prone to lose their structure and bioactivity under various environmental stressors. This study reports a facile approach using a nanoporous material, zeolitic imidazolate framework-8 (ZIF-8), as an encapsulant for preserving the prototypic protein therapeutic, insulin, against different harsh conditions that may be encountered during storage, formulation, and transport, including elevated temperatures, mechanical agitation, and organic solvent. Both immunoassay and spec ...[more]