Ontology highlight
ABSTRACT:
SUBMITTER: Zhu M
PROVIDER: S-EPMC6454295 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zhu Ming M Xu Bingxin B Wang Meng M Liu Shangyun S Zhang Yue Y Zhang Chao C
Endocrine connections 20190401 4
Melanocortin receptors (MCRs) and their accessory proteins (MRAPs) evolutionarily first appear in the genome of sea lamprey. The most ancient melanocortin system consists of only two melanocortin receptors (slMCa and slMCb) and one MRAP2 (slMRAP2) protein, but the physiological roles have not been fully explored in this primitive species. Here, we synthesize and characterize the pharmacological features of slMRAP2 protein on two slMCRs. Our results show that the slMRAP2 protein lacks the long ca ...[more]