Ontology highlight
ABSTRACT:
SUBMITTER: Chen IC
PROVIDER: S-EPMC5574981 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Chen I-Chun IC Chen I-Chun IC Hsiao Li-Ping LP Huang I-Wen IW Yu Huei-Chieh HC Yeh Ling-Chun LC Lin Ching-Hung CH Wei-Wu Chen Tom T Cheng Ann-Lii AL Lu Yen-Shen YS
Scientific reports 20170829 1
Tamoxifen is the standard first-line hormonal therapy for premenopausal women with estrogen receptor (ER)-positive metastatic breast cancer (BC). One of the crucial mechanisms underlying hormonal therapy resistance is the collateral activation of the phosphatidylinositol-3 kinase (PI3K)/AKT pathway. We explored whether PI3K inhibitors, buparlisib and alpelisib, enhance the efficacy of tamoxifen against ER-positive BC cells. We have observed a synergism between alpelisib or buparlisib and tamoxif ...[more]