Ontology highlight
ABSTRACT:
SUBMITTER: Lehner KR
PROVIDER: S-EPMC6455130 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lehner Kurt R KR Silverman Harold A HA Addorisio Meghan E ME Roy Ashbeel A Al-Onaizi Mohammed A MA Levine Yaakov Y Olofsson Peder S PS Chavan Sangeeta S SS Gros Robert R Nathanson Neil M NM Al-Abed Yousef Y Metz Christine N CN Prado Vania F VF Prado Marco A M MAM Tracey Kevin J KJ Pavlov Valentin A VA
Frontiers in immunology 20190402
The brain regulates physiological functions integral to survival. However, the insight into brain neuronal regulation of peripheral immune function and the neuromediator systems and pathways involved remains limited. Here, utilizing selective genetic and pharmacological approaches, we studied the role of forebrain cholinergic signaling in the regulation of peripheral immune function and inflammation. Forebrain-selective genetic ablation of acetylcholine release and vagotomy abolished the suppres ...[more]