Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC6456019 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Chen Tianchi T Callan-Jones Andrew A Fedorov Eduard E Ravasio Andrea A Brugués Agustí A Ong Hui Ting HT Toyama Yusuke Y Low Boon Chuan BC Trepat Xavier X Shemesh Tom T Voituriez Raphaël R Ladoux Benoît B
Nature physics 20190121
Cell migration over heterogeneous substrates during wound healing or morphogenetic processes leads to shape changes driven by different organizations of the actin cytoskeleton and by functional changes including lamellipodial protrusions and contractile actin cables. Cells distinguish between cell-sized positive and negative curvatures in their physical environment by forming protrusions at positive ones and actin cables at negative ones; however, the cellular mechanisms remain unclear. Here, we ...[more]