Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6456036 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zhao Yimu Y Rafatian Naimeh N Feric Nicole T NT Cox Brian J BJ Aschar-Sobbi Roozbeh R Wang Erika Yan EY Aggarwal Praful P Zhang Boyang B Conant Genevieve G Ronaldson-Bouchard Kacey K Pahnke Aric A Protze Stephanie S Lee Jee Hoon JH Davenport Huyer Locke L Jekic Danica D Wickeler Anastasia A Naguib Hani E HE Keller Gordon M GM Vunjak-Novakovic Gordana G Broeckel Ulrich U Backx Peter H PH Radisic Milica M
Cell 20190124 4
Tissue engineering using cardiomyocytes derived from human pluripotent stem cells holds a promise to revolutionize drug discovery, but only if limitations related to cardiac chamber specification and platform versatility can be overcome. We describe here a scalable tissue-cultivation platform that is cell source agnostic and enables drug testing under electrical pacing. The plastic platform enabled on-line noninvasive recording of passive tension, active force, contractile dynamics, and Ca<sup>2 ...[more]