Effects of receptor activator nuclear factor ?B gene polymorphisms on the susceptibility to knee osteoarthritis: A case-control study.

ABSTRACT: The present study aimed to explore genetic association of receptor activator nuclear factor ?B (RANK) polymorphisms with individual susceptibility to knee osteoarthritis (OA) in different Kellgren-Lawrence (KL) grades.This case-control study included 138 knee OA patients and 145 healthy individuals. RANK rs1805034 and rs8086340 polymorphisms were genotyped through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The effects of RANK polymorphisms on knee OA risk were analyzed via ? test or Fisher exact test, and the results were expressed using odds ratios (ORs) with corresponding 95% confidence intervals (CIs).The C allele of rs1805034 polymorphism had significantly higher frequency in knee OA patients than in controls (P?=?.044), indicating that this allele could increase the risk of knee OA (OR?=?1.424, 95% CI?=?1.010-2.008). Besides, the CC genotype and C allele of the rs1805034 polymorphism were significantly associated with elevated risk of knee OA in moderate grade (CC vs TT: P?=?.018, OR?=?3.071, 95% CI?=?1.187-7.941; C vs T: P?=?.012, OR?=?1.787, 95% CI?=?1.131-2.823). However, rs8086340 polymorphism had no significant association with knee OA riskThe C allele of RANK rs1805034 polymorphism is closely correlated with increased risk of knee OA, especially for moderate grade.

SUBMITTER: Wang C 

PROVIDER: S-EPMC6456093 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature