Ontology highlight
ABSTRACT:
SUBMITTER: Boland B
PROVIDER: S-EPMC6456907 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Boland Barry B Yu Wai Haung WH Corti Olga O Mollereau Bertrand B Henriques Alexandre A Bezard Erwan E Pastores Greg M GM Rubinsztein David C DC Nixon Ralph A RA Duchen Michael R MR Mallucci Giovanna R GR Kroemer Guido G Levine Beth B Eskelinen Eeva-Liisa EL Mochel Fanny F Spedding Michael M Louis Caroline C Martin Olivier R OR Millan Mark J MJ
Nature reviews. Drug discovery 20180817 9
Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. They are often called 'proteinopathies' owing to the presence of misfolded and aggregated proteins that lose their physiological roles and acquire neurotoxic properties. One reason underlying the accumulation and spread of oligomeric f ...[more]