Ontology highlight
ABSTRACT:
SUBMITTER: Ward RJ
PROVIDER: S-EPMC5672917 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
The Lancet. Neurology 20141001 10
<h4>Summary</h4>In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor an ...[more]