Ontology highlight
ABSTRACT:
SUBMITTER: Shi H
PROVIDER: S-EPMC6457195 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Chemical science 20190218 13
An oxidant-free Rh(iii)-catalyzed direct amidation of alkyl dithianes <i>via</i> C(sp<sup>3</sup>)-H bond activation utilizing diverse and robust dioxazolone reagents is reported. The reaction hinges on use of a Cp*Rh(iii) complex in combination with an essential amino-carboxylate additive to generate usefully protected 1,3-aminoaldehyde derivatives. The scalability of the reaction was demonstrated as was a series of downstream product functionalizations, including dithiane deprotection, anion a ...[more]