Ontology highlight
ABSTRACT:
SUBMITTER: Johnson LDS
PROVIDER: S-EPMC6457236 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Johnson Lisa D S LDS Banerjee Swati S Kruglov Oleg O Viller Natasja Nielsen NN Horwitz Steven M SM Lesokhin Alexander A Zain Jasmine J Querfeld Christiane C Chen Robert R Okada Craig C Sawas Ahmed A O'Connor Owen A OA Sievers Eric L EL Shou Yaping Y Uger Robert A RA Wong Mark M Akilov Oleg E OE
Blood advances 20190401 7
Sézary syndrome (SS), the leukemic variant of cutaneous T-cell lymphoma, has limited treatment options and rare occurrences of long-term remission, thus warranting research into new treatment approaches. CD47 has emerged as a promising target for multiple tumor types, but its role in SS remains unknown. Here, we show that CD47 is highly expressed on Sézary cells in the peripheral blood and skin, and the high level of CD47 expression correlates with worse overall survival (OS) in patients with SS ...[more]