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Quantifying dissipation using fluctuating currents.

ABSTRACT: Systems coupled to multiple thermodynamic reservoirs can exhibit nonequilibrium dynamics, breaking detailed balance to generate currents. To power these currents, the entropy of the reservoirs increases. The rate of entropy production, or dissipation, is a measure of the statistical irreversibility of the nonequilibrium process. By measuring this irreversibility in several biological systems, recent experiments have detected that particular systems are not in equilibrium. Here we discuss three strategies to replace binary classification (equilibrium versus nonequilibrium) with a quantification of the entropy production rate. To illustrate, we generate time-series data for the evolution of an analytically tractable bead-spring model. Probability currents can be inferred and utilized to indirectly quantify the entropy production rate, but this approach requires prohibitive amounts of data in high-dimensional systems. This curse of dimensionality can be partially mitigated by using the thermodynamic uncertainty relation to bound the entropy production rate using statistical fluctuations in the probability currents.

SUBMITTER: Li J

PROVIDER: S-EPMC6458151 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Quantifying dissipation using fluctuating currents.

Li Junang J Horowitz Jordan M JM Gingrich Todd R TR Fakhri Nikta N

Nature communications 20190410 1

Systems coupled to multiple thermodynamic reservoirs can exhibit nonequilibrium dynamics, breaking detailed balance to generate currents. To power these currents, the entropy of the reservoirs increases. The rate of entropy production, or dissipation, is a measure of the statistical irreversibility of the nonequilibrium process. By measuring this irreversibility in several biological systems, recent experiments have detected that particular systems are not in equilibrium. Here we discuss three s ...[more]

PMID: 30971687

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Dataset Information

Quantifying dissipation using fluctuating currents.

Publications

Quantifying dissipation using fluctuating currents.

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