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On moment of velocity for signal analysis.

ABSTRACT: The instantaneous frequency (IF) of a signal is a well-defined quantity that is widely used for analysing non-stationary signals. However, often in practice, IF as a function of time can possess large spikes and negative values. Moreover, IF is very sensitive to noise, limiting its range of practical application. Due to these deficiencies, we introduce the concept of moment of velocity (MoV) for signal analysis. As a case study, we compare the performance of MoV to a standard Hilbert transform-based approach for R-wave identification in human electrocardiogram signals, demonstrating that our approach is more robust to noise. We examine characteristic heartbeats obtained from the MIT-BIH Arrhythmia database. A detection error rate of 0.07%, a positive predictive value of 99.97%, and a sensitivity of 99.95% are achieved against analysis results from the database.

SUBMITTER: Dorraki M

PROVIDER: S-EPMC6458400 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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On moment of velocity for signal analysis.

Dorraki M M Fouladzadeh A A Allison A A Davis B R BR Abbott D D

Royal Society open science 20190327 3

The instantaneous frequency (IF) of a signal is a well-defined quantity that is widely used for analysing non-stationary signals. However, often in practice, IF as a function of time can possess large spikes and negative values. Moreover, IF is very sensitive to noise, limiting its range of practical application. Due to these deficiencies, we introduce the concept of moment of velocity (MoV) for signal analysis. As a case study, we compare the performance of MoV to a standard Hilbert transform-b ...[more]

PMID: 31032047

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Project description:BackgroundRate-varying S1S2 stimulation protocols can be used for restitution studies to characterize atrial substrate, ionic remodeling, and atrial fibrillation risk. Clinical restitution studies with numerous patients create large amounts of these data. Thus, an automated pipeline to evaluate clinically acquired S1S2 stimulation protocol data necessitates consistent, robust, reproducible, and precise evaluation of local activation times, electrogram amplitude, and conduction velocity. Here, we present the CVAR-Seg pipeline, developed focusing on three challenges: (i) No previous knowledge of the stimulation parameters is available, thus, arbitrary protocols are supported. (ii) The pipeline remains robust under different noise conditions. (iii) The pipeline supports segmentation of atrial activities in close temporal proximity to the stimulation artifact, which is challenging due to larger amplitude and slope of the stimulus compared to the atrial activity.Methods and resultsThe S1 basic cycle length was estimated by time interval detection. Stimulation time windows were segmented by detecting synchronous peaks in different channels surpassing an amplitude threshold and identifying time intervals between detected stimuli. Elimination of the stimulation artifact by a matched filter allowed detection of local activation times in temporal proximity. A non-linear signal energy operator was used to segment periods of atrial activity. Geodesic and Euclidean inter electrode distances allowed approximation of conduction velocity. The automatic segmentation performance of the CVAR-Seg pipeline was evaluated on 37 synthetic datasets with decreasing signal-to-noise ratios. Noise was modeled by reconstructing the frequency spectrum of clinical noise. The pipeline retained a median local activation time error below a single sample (1 ms) for signal-to-noise ratios as low as 0 dB representing a high clinical noise level. As a proof of concept, the pipeline was tested on a CARTO case of a paroxysmal atrial fibrillation patient and yielded plausible restitution curves for conduction speed and amplitude.ConclusionThe proposed openly available CVAR-Seg pipeline promises fast, fully automated, robust, and accurate evaluations of atrial signals even with low signal-to-noise ratios. This is achieved by solving the proximity problem of stimulation and atrial activity to enable standardized evaluation without introducing human bias for large data sets.

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On moment of velocity for signal analysis.

Publications

On moment of velocity for signal analysis.

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