Ontology highlight
ABSTRACT:
SUBMITTER: Winters BL
PROVIDER: S-EPMC5364458 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Winters Bryony L BL Gregoriou Gabrielle C GC Kissiwaa Sarah A SA Wells Oliver A OA Medagoda Danashi I DI Hermes Sam M SM Burford Neil T NT Alt Andrew A Aicher Sue A SA Bagley Elena E EE
Nature communications 20170322
Fear and emotional learning are modulated by endogenous opioids but the cellular basis for this is unknown. The intercalated cells (ITCs) gate amygdala output and thus regulate the fear response. Here we find endogenous opioids are released by synaptic stimulation to act via two distinct mechanisms within the main ITC cluster. Endogenously released opioids inhibit glutamate release through the δ-opioid receptor (DOR), an effect potentiated by a DOR-positive allosteric modulator. Postsynaptically ...[more]