Ontology highlight
ABSTRACT:
SUBMITTER: Bolotta A
PROVIDER: S-EPMC6458886 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Bolotta Alessandra A Abruzzo Provvidenza Maria PM Baldassarro Vito Antonio VA Ghezzo Alessandro A Scotlandi Katia K Marini Marina M Zucchini Cinzia C
Oxidative medicine and cellular longevity 20190327
Iron homeostasis in the cardiac tissue as well as the involvement of the hepcidin-ferroportin (HAMP-FPN) axis in this process and in cardiac functionality are not fully understood. Imbalance of iron homeostasis occurs in several cardiac diseases, including iron-overload cardiomyopathies such as Friedreich's ataxia (FRDA, OMIM no. 229300), a hereditary neurodegenerative disorder. Exploiting the induced pluripotent stem cells (iPSCs) technology and the iPSC capacity to differentiate into specific ...[more]