Defining the genetic and evolutionary architecture of alternative splicing in response to infection.
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ABSTRACT:
SUBMITTER: Rotival M
PROVIDER: S-EPMC6459842 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Defining the genetic and evolutionary architecture of alternative splicing in response to infection.
Rotival Maxime M Quach Hélène H Quintana-Murci Lluis L
Nature communications 20190411 1
Host and environmental factors contribute to variation in human immune responses, yet the genetic and evolutionary drivers of alternative splicing in response to infection remain largely uncharacterised. Leveraging 970 RNA-sequencing profiles of resting and stimulated monocytes from 200 individuals of African- and European-descent, we show that immune activation elicits a marked remodelling of the isoform repertoire, while increasing the levels of erroneous splicing. We identify 1,464 loci assoc ...[more]
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