Ontology highlight
ABSTRACT:
SUBMITTER: Sharma BR
PROVIDER: S-EPMC6460383 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Sharma Bhesh Raj BR Karki Rajendra R Lee Ein E Zhu Qifan Q Gurung Prajwal P Kanneganti Thirumala-Devi TD
Cell death and differentiation 20180723 4
Mice deficient in SHANK-associated RH domain-interacting protein (SHARPIN), a component of the linear ubiquitin chain assembly complex (LUBAC), develop a spontaneous inflammatory disorder with pathologic hallmarks similar to atopic dermatitis and psoriasis in humans. Previous studies identified the crucial role of components of the TNF and IL-1 signaling pathways in the progression of disease in SHARPIN-deficient mice. However, an innate immune adaptor or sensor that relates to the disease progr ...[more]