Ontology highlight
ABSTRACT:
SUBMITTER: Song W
PROVIDER: S-EPMC6460434 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Song Wenqian W Wang Ran R Jiang Weimin W Yin Qi Q Peng Guangdun G Yang Ruikai R Yu Qing Cissy QC Chen Jianfeng J Li Jingsong J Cheung Tom H TH Jing Naihe N Zeng Yi Arial YA
Cell research 20190110 3
In the mammary gland, it is widely believed that the luminal cells are unipotent after birth, contributing only to the luminal compartment in normal development. Here, by lineage tracing, we uncovered an unexpected potential of luminal cells that can give rise to basal cells during pregnancy. These luminal-derived basal cells (LdBCs) persisted through mammary regression and generated more progeny in successive rounds of pregnancies. LdBCs express basal markers as well as estrogen receptor α (ERα ...[more]