Ontology highlight
ABSTRACT:
SUBMITTER: Peloso GM
PROVIDER: S-EPMC6460910 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Peloso Gina M GM Beiser Alexa S AS Destefano Anita L AL Seshadri Sudha S
Journal of Alzheimer's disease : JAD 20180101 3
Epidemiological and genetic studies have pointed to the role of cholesterol in Alzheimer's disease (AD). We explored the interaction of a genetic risk score (GRS) of AD risk alleles with mid-life plasma lipid levels (LDL-C, HDL-C, and triglycerides) on risk for AD in the Framingham Heart Study (FHS). Mid-life (between the ages of 40-60 years old) lipid levels were obtained from individuals in the FHS Original and Offspring cohorts (157 cases and 2,882 controls) with genetic data and AD status av ...[more]