Dataset Information

Salivary LDOC1 is a gender-difference biomarker of oral squamous cell carcinoma.

ABSTRACT:

Background

The X-linked tumor suppressor gene LDOC1 is reported to be involved in oral cancer. The detection of biomarkers in salivary RNA is a non-invasive strategy for diagnosing many diseases. The aim of the present study was to investigate the potential of salivary LDOC1 as a biomarker of oral cancer.

Methods

We determined the expression levels of LDOC1 in the saliva of oral squamous cell carcinoma (OSCC) subjects, and investigated its correlation with various clinicopathological characteristics. The expression levels of salivary LDOC1 were detected in 53 OSCC subjects and 43 healthy controls using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. We used Fisher's exact test to analyze the correlations between expression levels and clinicopathological characteristics.

Results

Salivary LDOC1 was significantly upregulated in females with OSCC (p = 0.0072), and significantly downregulated in males with OSCC (p = 0.0206). Eighty-nine percent of male OSCC subjects who smoked expressed low levels of LDOC1. OSCC cell lines derived from male OSCC subjects expressed low levels of LDOC1.

Conclusions

A high level of salivary LDOC1 expression is a biomarker of OSCC in females. A high percentage of male OSCC subjects who smoke express low levels of salivary LDOC1. A low level of salivary LDOC1 expression is a biomarker of OSCC in males.

SUBMITTER: Liu CJ

PROVIDER: S-EPMC6461027 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Salivary <i>LDOC1</i> is a gender-difference biomarker of oral squamous cell carcinoma.

Liu Chung-Ji CJ Chen Jen-Hao JH Hsia Shih-Min SM Liao Chiu-Chu CC Chang Hui-Wen HW Shieh Tzong-Ming TM Shih Yin-Hwa YH

PeerJ 20190409

<h4>Background</h4>The X-linked tumor suppressor gene <i>LDOC1</i> is reported to be involved in oral cancer. The detection of biomarkers in salivary RNA is a non-invasive strategy for diagnosing many diseases. The aim of the present study was to investigate the potential of salivary <i>LDOC1</i> as a biomarker of oral cancer.<h4>Methods</h4>We determined the expression levels of <i>LDOC1</i> in the saliva of oral squamous cell carcinoma (OSCC) subjects, and investigated its correlation with var ...[more]

PMID: 30993049

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