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Identification of potential salivary biomarker panels for oral squamous cell carcinoma.


ABSTRACT: Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide with the maximum number of incidences and deaths reported from India. One of the major causes of poor survival rate associated with OSCC has been attributed to late presentation due to non-availability of a biomarker. Identification of early diagnostic biomarker will help in reducing the disease morbidity and mortality. We validated 12 salivary proteins using targeted proteomics, identified initially by relative quantification of salivary proteins on LC-MS, in OSCC patients and controls. Salivary AHSG (p?=?0.0041**) and KRT6C (p?=?0.002**) were upregulated in OSCC cases and AZGP1 (p???0.0001***), KLK1 (p?=?0.006**) and BPIFB2 (p?=?0.0061**) were downregulated. Regression modelling resulted in a significant risk prediction model (p?

SUBMITTER: Jain A 

PROVIDER: S-EPMC7873065 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Identification of potential salivary biomarker panels for oral squamous cell carcinoma.

Jain Anu A   Kotimoole Chinmaya Narayana CN   Ghoshal Sushmita S   Bakshi Jaimanti J   Chatterjee Aditi A   Prasad Thottethodi Subrahmanya Keshava TSK   Pal Arnab A  

Scientific reports 20210209 1


Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide with the maximum number of incidences and deaths reported from India. One of the major causes of poor survival rate associated with OSCC has been attributed to late presentation due to non-availability of a biomarker. Identification of early diagnostic biomarker will help in reducing the disease morbidity and mortality. We validated 12 salivary proteins using targeted proteomics, identified initially by relative q  ...[more]

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