Ontology highlight
ABSTRACT:
SUBMITTER: Morton EL
PROVIDER: S-EPMC6461408 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Morton Emily L EL Forst Christian V CV Zheng Yue Y DePaula-Silva Ana B AB Ramirez Nora-Guadalupe P NP Planelles Vicente V D'Orso Iván I
Cell reports 20190401 1
Transcriptional circuit architectures in several organisms have been evolutionarily selected to dictate precise given responses. Unlike these cellular systems, HIV is regulated through a complex circuit composed of two successive phases (host and viral), which create a positive feedback loop facilitating viral replication. However, it has long remained unclear whether both phases operate identically and to what extent the host phase influences the entire circuit. Here, we report that, although t ...[more]