Ontology highlight
ABSTRACT:
SUBMITTER: Ma H
PROVIDER: S-EPMC6461585 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ma He H Zhang Bao Li BL Liu Bao Ying BY Shi Shuo S Gao Da Yuan DY Zhang Tian Cheng TC Shi Hui Juan HJ Li Zhen Z Shum Winnie Waichi WW
iScience 20190329
A low-calcium microenvironment is essential for spermatozoa to mature in the epididymis; however, it remains unclear how dysregulation of epididymal luminal calcium is associated with male infertility. Using a warfarin-induced vitamin K2 deficiency rat model, we found that vitamin-K-dependent γ-glutamyl carboxylase (GGCX) and matrix Gla protein (MGP) were essential in extracellular calcium signaling of the intercellular communication required for epididymal sperm maturation. We found that GGCX a ...[more]