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Investigating brain d-serine: Advocacy for good practices.

ABSTRACT: The last two decades have witnessed remarkable advance in our understanding the role of d-amino acids in the mammalian nervous system: from the unknown, to known molecules with unknown functions, to potential central players in health and disease. d-Amino acids have emerged as an important class of signaling molecules. In particular, the exploration of the roles of d-serine in brain physiopathology is a vibrant field that is growing at an accelerating pace. However, disentangling the functions of a chiral molecule in a complex chemical matrice as the brain requires specific measurement and detection methods but is also a challenging task as many molecular tools and models investigators are using can lead to confounded observations. Thus, study of d-amino acids demands accurate methodologies and specific controls, and these have often been lacking. Here we outline best practices for d-amino acid research, with a special emphasis on d-serine. We hope these concepts help move the field to greater rigor and reproducibility, allowing the field to advance.

SUBMITTER: Mothet JP

PROVIDER: S-EPMC6462235 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Investigating brain d-serine: Advocacy for good practices.

Mothet Jean-Pierre JP Billard Jean-Marie JM Pollegioni Loredano L Coyle Joseph T JT Sweedler Jonathan V JV

Acta physiologica (Oxford, England) 20190214 1

The last two decades have witnessed remarkable advance in our understanding the role of d-amino acids in the mammalian nervous system: from the unknown, to known molecules with unknown functions, to potential central players in health and disease. d-Amino acids have emerged as an important class of signaling molecules. In particular, the exploration of the roles of d-serine in brain physiopathology is a vibrant field that is growing at an accelerating pace. However, disentangling the functions o ...[more]

PMID: 30650253

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Dataset Information

Investigating brain d-serine: Advocacy for good practices.

Publications

Investigating brain d-serine: Advocacy for good practices.

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