Ontology highlight
ABSTRACT:
SUBMITTER: He J
PROVIDER: S-EPMC6462779 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
He Jieyan J Li Tianshu T Próchnicki Tomasz T Horvath Gabor G Latz Eicke E Takeoka Shinji S
Biochemistry and biophysics reports 20190412
Lysine (K) type cationic lipid with a propyl spacer and ditetradecyl hydrophobic moieties composing liposomes, K3C14, previously studied for gene delivery, were reported to activate the NLRP3 inflammasomes in human macrophages via the conventional phagolysosomal pathway. In this study, K3C16, a propyl spacer bearing lysine type lipids with dihexadecyl moieties (an extension of two hydrocarbon tail length) were compared with K3C14 as liposomes. Such a small change in tail length did not alter the ...[more]