Ontology highlight
ABSTRACT:
SUBMITTER: Hofbauer B
PROVIDER: S-EPMC6462815 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Biochemistry 20180301 11
Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a phenotypic screen of 35 molecules that were structurally inspired by previous hydroxyamide-based S. aureus virulence inhibitors compiled from commercial sources or designed and synthesized de novo. One of the most potent compounds, AV73, not only reduced hemolytic alpha-hemolysin production in S. aureus but also impeded in vitro biofilm formation. ...[more]