Ontology highlight
ABSTRACT:
SUBMITTER: Green DP
PROVIDER: S-EPMC6462816 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Neuron 20190124 3
Mast cells can be found in close proximity to peripheral nerve endings where, upon activation, they release a broad range of pro-inflammatory cytokines and chemokines. However, the precise mechanism underlying this so-called neurogenic inflammation and associated pain has remained elusive. Here we report that the mast-cell-specific receptor Mrgprb2 mediates inflammatory mechanical and thermal hyperalgesia and is required for recruitment of innate immune cells at the injury site. We also found th ...[more]